Contributes to the reduction of tiredness and fatigue
- Unique fomula with documented high bioavailability
- 20 years of consumer experience on safety and efficacy
- Documentation from more than 100 scientific studies
- The Q10 in the preparation is identical to the Q10-form, the body produces
- It is the natural all-trans form, which is free of synthetic cis-isomers
- Identical to the natural form of Q10
- Official reference product for ICQA (International Coenzyme Q10 Association)
- Q10 100 contains Q10 in vegetable oil in soft lightproof gelatin capsules
- Unique blend of vegetable oils from sustainable farming
- Added vitamin B2, which contributes to the reduction of tiredness and fatigue plus a normal energy-yielding metabolism
- Manufactured under Danish pharmaceutical control
BioActive Q10 Gold 100 mg
- Product Facts
- Q10 quality
- What is Q10?
|1 capsule contains||% NRV*|
|Vitamin B2||1.4 mg||100%|
|Ubidecarenone (Co-enzyme Q10)||100 mg||**|
* NRV: Nutrient Reference Value.
** NRV not established.
1 capsule per day or as recommended by a physician. To be taken with food.
Do not exceed recommended amount.
Not suitable for vegetarians.
Pregnant and lactating women and those on medication should seek professional advice prior to taking supplements.
Nutritional supplements should not be used as a substitute for a varied diet and a healthy lifestyle.
Patented manufacturing method, EP 3 190 898 B1.
Bulking agent: Soybean Oil*
Capsule shell: Gelatine
Bulking Agent: Mixture of hydrogenated soybean oils (partly hydrogenated)*
Humectants: Glycerol, purified water
Colours: Iron oxide, riboflavin
Room temperature out of direct sunlight. Keep out of reach of children.
* Does not contain phytoestrogens (estrogenic substances)
BioActive Q10 Gold 100 mg?
For several decades, BioActive Q10 Gold 100 mg has been one of the world’s most widely sold Q10 brands. One of the main reasons for its popularity is that fact that this preparation can document a high level of bio-availability. Q10 is a fat-soluble substance which is difficult for the body to absorb. However, thanks to a highly specialized manufacturing process where Q10 is dissolved in a vegetable oil solution and exposed to a unique heating process the Q10 molecules are able to dissolve entirely at normal body temperature. The fact that the Q10 raw material dissolve completely in this product is the reason why BioActive Q10 Gold 100 mg can deliver such superior bioavailability of its active compound.
A very safe substance
Studies show that long-term supplementation with Q10 does not affect the body’s endogenous production of the substance. More than 20 years of research and consumer experience support the safety of BioActive Q10 Gold 100 mg.
A high quality product - BioActive Q10
Pharma Nord has spent more than 25 years developing and optimizing BioActive Q10 for the sole purpose of producing a Q10 preparation which scientifically can document it's superior bioavailability and quality. It is these targeted efforts that is the reason why
BioActive Q10 today is the most sold Q10-brand in Europe and is also the Q10 preparation, that officially is used in international Q10 research represented by the International Coenzyme Q10 Association (ICQA).
Optimal oil formulation
A number of clinical studies have demonstrated that the BioActive Q10 composition with it's content of Q10 dissolved in vegetable oil and encapsulated in soft gelatin away from light, gives a higher bioavailability than any other composition formulations. (Ref. 1)
BioActive Q10's oil formulation provides higher bioavailability than other formulations
- Ref. 1. Weis M, et al. Bioavailability of Four Oral Coenzyme Q10 Formulations in Healthy Volunteers. Mol Aspect Med 199415s,273-80.
High bioavailability at body temperature
One of the main reasons for Q10 100 Pharma Nord's superior bioavailability is the unique technique used for dissolving Q10 in oil.
Q10, which is not subjected to any pre-treatment, has a crystal form which prevents an efficient uptake. (Ref. 2)
A poorly composition typically contains a mixture of Q10-crystals and oil, which results in poor bioavailability of the substance.
BioActive Q10 has undergone a special heat treatment that changes the crystal structure to something similar to "snowflakes"
These "snowflakes" are dissolved completely at body temperature, thus forming a uniform (homogeneous) mixture that the body can easily absorb.
Dose and dosage
It is not only the formulation of the preparation that determines how much Q10 the body absorbs. It also depends on the dose and the dose intervals.
Data from a total of seven different human studies have shown that if you take two daily doses of Q10 at 100 mg each, you get a higher bioavailability than when you take a single dose of 200 mg.
- Ref. 2. Singh RB, et al. Effects on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men. Biofactors 2005;25(1-4):219-24.
Raw materials of the highest quality
BioActive Q10 Gold contains 100% natural Q10. The raw material is a pharmaceutical quality and is identical to the Q10 produced by the body. This fermented Q10 does not contain impurities of unknown nature. The raw material is also completely free of the unhealthy cis-isomers, which can be found in cheap synthetic Q10 raw materials of low quality, which is normally produced from waste products from the tobacco industry.
All raw materials used in BioActive Q10 Gold undergo an extensive quality control before production of each batch.
Unique production technique
Q10 is to some extent sensitive to sunlight and oxygen. The oil that is used in BioActive Q10 Gold is purged of oxygen by means of a special technique. Furthermore, the capsules are effectively protected from light to prevent the active ingredients in the capsules from being damaged or destroyed.
All Pharma Nord's products, both drugs as dietary supplements are manufactured in full compliance with the rules of Good Manufacturing Practice (GMP) and Hazard Analysis and Critical Control Points (HACCP). The entire Pharma Nord production meet the strict quality rules that belong to these schemes.
Every step of the production process takes place under full quality control. Everything from mixing of raw materials and packing of the finished goods to transport of the products are continuously point-checked to ensure that there is complete control with the content of each capsule right until the moment when the customers holds the products in their hands.
All Pharma Nord's products are based on thorough scientific research. Pharma Nord's own research department is continuously working to be fully abreast of the latest knowledge about health and nutrition. This requires a careful monitoring of the research progress and also planning and conduct of investigations of Pharma Nord's products in cooperation with the leading Q10 experts in the world.
Excellent safety profile
Q10 is a very safe drug. There are not registered any serious side effects in controlled trials, even at doses of 1200 mg daily for one year. (Ref.3)
After discontinuation of supplementation the body's Q10 level will return to the same level as before the start of the supplementation study. This shows that Q10 supplementation does not affect the body's own ability to form the substance .
Pharma Nord has a complete security file on Q10 100 Pharma Nord and more than 100 published scientific studies.
- Ref 3. Horstink MW, et al. The effect of coenzyme Q10 therapy in Parkinson disease could be symptomatic. Arch Neurol 2003;60(8):1170-72.
One of the best-documented Q10 products
Many people use coenzyme Q10 daily, but are perhaps not aware that there can be large differences in the products.
If you are in doubt whether you use the right product, you can try to test your current Q10 product against Q10 100, The world's most widespread Q10 brand:
|Q10 100 Pharma Nord||My current
|More than 20 years of consumer experience in EU||Yes||?|
|Scientific evidence for bioavailability||Yes||?|
|Scientific data on safety||Yes||?|
|Scientific evidence of effectiveness||Yes||?|
|Reference product in international research Q10||Yes||?|
|Produced in Denmark under GMP control after drug standardisation||Yes||?|
|Nature Identical Q10 - ie. Identical to the form the body uses||Yes||?|
|Tested and proven in more than 90 scientific studies||Yes||?|
|Documentation that the product does not affect the body's own production of Q10||Yes||?|
|Used daily by thousands of consumers in more than 40 countries||Yes||?|
|A unique matrix of oil and heating method ensures that
the Q10-crystals are dissolved in the stomach and can be absorbed
Q10 100 Pharma Nord is EU's first product and contains easily absorbable Q10, which helps produce energy in body's cells and thus reduces fatigue and lassitude and contributes to healthy blood vessels.
Q10 100 Pharma Nord - when you want to pay a little more for quality and safety.
1. Weis M, Mortensen SA, Rassing MR, Møller-Sonnergaard J et al.: Bioavailability of Four Oral Coenzyme Q10 Formulations in Healthy Volunteers; Mol Aspects Med 1994 15s, 273-280.
2. Singh RB; Niaz MA; Kumar A; Sindberg CD; Moesgaard S; Littarru GP:Eff ect on absorption and oxidative stress of diff erent oral Coenzyme Q10 dosages and intake strategy in healthy men.: Biofactors.: 25:1-4:219-24. (2005).
3. Horstink MW, van Engelen BG: The eff ect of coenzyme Q10 therapy in Parkinson disease could be symptomatic.; Arch Neurol 2003 60, no. 8, 1170-72
4. Langsjoen P, et al. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med. 1994;15 Suppl:S265-72.
5. Mortensen SA. Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (ubiquinone). Clin Investig. 1993;71(8 Suppl):S116-23.
Coenzyme Q10 (or just Q10) is a vitamin-like substance. It's also called ubiqinon (ubi is Latin and means ”everywhere”). Q10 100 Pharma Nord contains vitamin B2 that contributes to a normal energy-yielding metabolism. When a cell needs energy it convert fat, carbohydrate, protein, and alcohol to the ATP (adenosine triphosphate), a molecule that stores energy in its chemical form. The cell breaks down the ATP molecule and releases the energy trapped inside. The entire process takes place inside the cells in some small bean-shaped structures called mitochondria. In all mitochondria coenzyme Q10 is found. Muscle cells are particularly dependent on large amounts of energy, which is why muscle cells contain substantially more mitochondria than other types of cells. The heart muscle is a good example of body tissue with cells that contain a large number of mitochondria and have a correspondingly large energy requirement.
Good Q10 sources
We get Q10 from several types of food, some of the best sources of Q10 in food are::
- organ meat
- soy oil
In addition, humans are able to synthesize Q10 in the body. The process, which takes place in the liver, slows down as we grow older and as a result of disease. According to experts, the body’s Q10 levels peak at the age of 20-25 years from which point it begins on a downward slope.
Science has not been able to quantify exactly how much Q10 is provided by means of the diet but it is estimated to be somewhere around 5-20 mg daily. The body has a Q10 reserve that amounts to about 1 – 1.5 grams. The highest concentrations are found in the heart, liver, and kidneys.
Big difference in Q10 products
Pharma Nord has spent more than 20 years documenting the absorbability, effectiveness, and safety of the product Q10 100 Pharma Nord. But many Q10 products are currently sold without any documentation which may give the user assurance of an effect. In the wake of this a number of claims has emerged about what kind of Q10 is best. A team of U.S. Researchers has reviewed and weeded out the false claims. What remains are the facts about the effect and use of Q10.
Unprocessed Q10 poorly absorbed
Optimum absorbability has been the keyword in the development of Q10 100, and this is documented in approx. 40 scientific studies.
One of the biggest challenges associated with Q10 as a supplement is that the substance generally is not readily absorbed by the body. Q10 in other words, has a low bioavailability. The Q10 molecule is a relatively large molecule and this is the main reason for its poor absorbtion in the body and as a result of its molecular structure, it is fat soluble.
Slowly release into the blood
Q10 is absorbed in the intestinal wall along with fat and is then transported by the lymph wessels to the subclavian vein, where it emptied into the venous blood. This slow mode of transport results in a maximum concentration of Q10 in the blood approximately 6 hours after ingestion. Therefore, it is preferable to take Q10 with breakfast or perhaps lunch. If you take more than 1 capsule daily, the effect is larger by spreading the dose throughout the day - eg. one capsule at breakfast and one capsule at lunch time - rather than taking the the daily dosage at once.
Crystals are not absorbed
A Q10 100 capsule contains a special oil matrix in which the substance Q10 is in a molecular form. The starting point for all products is the Q10 raw material consisting of crystals, which in practice are not absorbed by the body. Q10 must be dissolved into single Q10 molecules before they can be absorbed. Less than 1% of Q10 is absorbed from products solely consisting of crystalline Q10, typically tablet products and hard capsules using unprocessed Q10 crystals. The crystals may be dissolved by using a special oil mixture, and a subsequent heating method, thereby, releasing Q10 into single molecules, which provides a quick and good absorption with oil.
Q10 always fat-soluble
A marketing strategy has gone on to claim that it is better to make Q10 water soluble, but neither a change to the Q10 molecule or placement of the fat-soluble Q10 molecules in liposomes (small spheres with an outer fatty membrane and an inner aqueous membrane) or linking Q10 to micelles (small spheres with a fatty core and a water-loving surface) or attaching nano-particles to Q10 will make the Q10 molecule more water soluble.
If you try, you just end up with an even bigger Q10 molecule complex, but no increased bioavailability and the Q10 molecule will still predominantly be fat soluble. If you choose to go the opposite way and make the molecule smaller, this will surely make the molecule more water soluble and more absorbable, but such a reduced molecule will no longer be Q10, but would be reduced to Q9 or Q8 which is of no value to humans.
Most documentation on Ubiqinon
Q10 is found in two forms. An oxidized form called ubiqinon as well as a reduced form called ubiquinol. Ubiquinol is also called active Q10. The kind of Q10 we produce in the liver is the oxidized ubiqinon. Q10 from our food is also the oxidized form. In the lymphatic system or the blood oxidized Q10 is changed to active Q10. Therefore, the 90-95% of blood Q10 is the active form. In the cells' energy-producing mitochondria Q10 continuously is shifting between these two forms, a property which is crucial for Q10s effects in the body.
Therefore, it is makes no difference what form you consume, your body will still convert oxidized Q10 into active Q10. To date, almost all evidence of efficacy and safety are done with the oxidized form, ubiqinon.
- Ubiqinon = oxidized Q10
- Ubiqinol = reduced Q10
Pharma Nord Q10 used in the Q-Symbio study
Pharma Nord Q10 does it again: It has occupied the headlines in health news journals around the world. Most recently, Professor Sven Aage Mortensen from Rigshospitalet in Copenhagen and his colleagues in EU and Asia presented the results of the Q-symbio study at a congress of cardiologists in Lisbon, Portugal, 23 - 28 May 2013.
420 patients from nine different countries were included in the Q-symbio study which examined the effect of Q10 supplementation on individuals believed be deficient.
Pharma Nord's Q10 dissolved in palm oil
The active treatment consisted of a soft gelatin capsule with 100 mg of Q10 three times a day for two years. The study wanted to show how well those who got Q10 performed compared to those who received the placebo.
Last year we saw another study involving healthy elderly people, in the so-called KiSel-10 study. Dr. Urban Alehagen and his team used the same Pharma Nord Q10 with the selenium product SelenoPrecise – and achieved similarly impressive results.
Why Q10 Pharma Nord?
Researchers prefer Pharma Nord Q10 because it has documentation from more than 100 scientific studies which highlights its high bioavailability and safety. It is manufactured under Danish pharmaceutical control and is the official reference product for ICQA (International Coenzyme Q10 Association).
Q10 Pharma Nord is a registered medicine in several other European countries.
|1 - Is Q10 on the doping list?|
|2 - What kind of Q10 is best absorbed?|
Various Q10 products are available either as tablets or as capsules. The Q10 content may be in the form of crystals or granules, encapsulated in liposomes, in micelles attached to nanoparticles or dissolved in oil.
The size alone of the Q10 molecule - it has a considerable size, approx. 5.5 nm long and 864 times heavier than a hydrogen atom - means that Q10 is basically not an easily absorbed substance. The Q10 raw material is an organic orange brown crystalline powder and Q10 crystals are too large to be absorbed into the body. The uptake of unprocessed Q10 powder and of tablets is therefore very poor. In addition, Q10 is a fat-soluble substance that has to be absorbed in the small intestine along with fat. It is possible to attach other substances to the Q10 molecule that will make it somewhat more water-soluble, but doing so will make the big Q10 molecule even bigger, whereby the advantage disappears, and the Q10 complex will still largely be fat-soluble. It sounds impressive to state that a Q10 product is three times more absorbable than a competing product, but if the competing product simply consists of Q10 crystals with a less than 1% absorption rate, the claim is not particularly impressive. Producers of Q10 supplements have to treat the Q10 raw material in a special way in order to achieve an effective absorption. The most bioavailable Q10 products are dissolved in a vegetable oil in which the crystals must be dissolved completely.
|3 - Why can't I feel the effect of Q10?|
Many so-called energy-based products get their effect from caffeine and caffeine-like substances from various plants that stimulate the adrenal glands to secrete stress hormones. Coenzyme Q10, on the other hand, is present in all body cells and is part of the cells’ natural way of producing energy. Thus, the biochemical processes in the body and the experience are not the same for these two different types of products. The fact that you may not feel an immediate effect of Q10 may also be due to one or more of the following factors:
|4 - How do I Make the Most of my Q10 Product?|
It is recommended to avoid taking very high doses of Vitamin E (>250 mg) while taking Q10.
The trace element selenium is part of the seleno protein thioredoxin reductase, which helps in reducing ubiquinone to ubiqionol in the body.
Furthermore, you can take a supplement of the amino acid carnitine, which interacts closely with Q10 in the cells' mitochondria. Carnitine helps with the transport of fatty acids into the mitochondria, and Q10 is involved in the oxidation process that converts these fatty acids into energy in the form of ATP.
|5 - How do I optimize the body's own production of Q10?|
|6 - What are the best dietary sources of Q10?|
Cereal products usually contain Coenzyme Q9, whereas soybeans do contain some Q10. There is also some Q10 in walnuts, almonds, oil-rich fruits and green vegetables, especially spinach. Furthermore, fish contains Q10, especially sardines, which contain twice as much Q10 as beef. Even so, one would have to eat one pound of sardines, two pounds of beef, or 2.5 pounds of peanuts in order to get 30 mg of Q10.
|7 - Are there adverse effects from Q10?|
|8 - How long can I take Q10?|
|9 - What is the difference between oxidized Q10 (ubiquinone) and reduced Q10 (ubiquinol)?|
At the molecular level, the difference between ubiquinone (oxidized Q10) and ubiquinol (reduced Q10) is not big. Ubiquinol has two extra hydrogen ions and forms, in conjunction with oxygen, a so-called hydroxyl group on the head of the Q10 molecule, which is a quinone ring.
The two forms of Q10, however, have quite different roles in the body. Ubiquinol donates electrons, whereas ubiquinone receives electrons. Ubiquinol performs an important function as an antioxidant in the body, but in the cells' energy producing mitochondria, the two forms constantly switch from the one form to the other - that is, from the oxidized to the reduced form and back again. Thus, one cannot say that one form of Q10 is more active or more important than the other.
The two forms of Q10 also have different colors. Normal Q10 is a clear orange, yellowish substance, whereas reduced Q10, which is oxidatively unstable, has a milky-white color. It is therefore easy to test whether the product you buy is normal or reduced Q10. The Q10 that we produce in the body's cells is oxidized Q10, whereas 90-95% of Q10 circulating in the blood is in the form of reduced Q10.
Q10 from the diet consists of both ubiquinone and ubiquinol, about half of each. Both forms are absorbed in the intestine along with fat. Q10 is slowly transported from the lymph into the blood. Already during the passage through the intestinal wall into the lymph, the absorbed ubiquinone is being converted into reduced ubiquinol. Consequently, there is no good reason to choose a product containing ubiquinol, as your body is able to absorb and convert ubiquinone from the gut to ubiquinol. The body is naturally able to reduce ubiquinone Q10 by itself.
Q10 product's ability to be absorbed from the intestine is one of its most important aspects. Ubiquinone of good quality has been found to be absorbed better than ubiquinol. A few unsubstantiated reports suggest, however, that products with ubiquinol may be relevant to a very small percentage of people who have impaired uptake of Q10 from the gut.
Finally, ubiquinol preparations are usually more expensive to buy than ubiquinone preparations.
|10 - Does cholesterol lowering drugs reduce the body's level of Q10?|
There are different types of statins working in different ways, and they are not equally strong. The most common complaint about the adverse effects of statins is muscle pain. The pain occurs when the muscles have to work with too little energy. However, not everybody experiences adverse effects from statins.
The effect differs from individual to individual depending on how much Q10 is required to normalize the body's Q10 level during statin treatment. You should consult your doctor in such cases.
|11 - How much Q10 do we need?|
|12 - How long does it take for Q10 to work?|
In practical terms, this means that it is advisable to start with a slightly higher daily dose and then reduce the dose after some time if necessary. Take Q10 for at least a month, but do not expect maximum absorption in the tissue until after at least six months of use.
|13 - What is the source of Pharma Nord's Q10?|
|14 - Do I risk infection from Mad Cow Disease from the Softgel Capsules?|
All animals are examined before and after slaughter at an authorized slaughterhouse prior to approval. The gelatin is produced exclusively from bovine (cow) hides from animals approved for human consumption. Risk materials like brain and spine are not used for gelatin production. Animals from risk countries are not used at all.
|15 - How can I avoid eating the gelatin in the Q10 capsules?|
|16 - Is the gelatin in your Q10 capsules Halal certified?|
|17 - What is the best way to store the Q10 softgels?|
The softgels can tolerate a temperature higher than room temperature, which will not damage the content, even if they become very soft, but the temperature should not exceed 86° F (30° C) for a long period of time.